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Related evaluation of their clinical application is still rare [267]

Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome

The antioxidant system involved in the defense against ferroptosis is mainly controlled by the transcription factor nuclear factor erythroid-2-related factor (NRF2), which is known to induce the expression of antioxidant enzymes and lipid detoxification enzymes [46]